Grey's Anatomy
2005 · 22 Seasons · ABC · Medical Drama / Romance
The longest-running primetime medical drama in American television history, and a show that has survived more cast departures, character deaths, and natural disasters than most soap operas dream of. Grey's Anatomy built its legacy on the strength of its early seasons, when Meredith Grey's intern class felt fresh and the emotional stakes hit hard, and has sustained itself through sheer force of formula and a fanbase that has grown up alongside the show. The first five seasons are peak Shonda Rhimes. Everything after varies wildly, but the show's ability to generate big emotional moments has never completely disappeared.